Superoxide Dismutase 1 (SOD1) is used in the cell to get rid of naturally occurring yet harmful superoxide radicles in the body. When mutated the SOD1 accumulates in the motor neurons causing them to shut down.
When the aggregates are isolated, by sonication and centrifugation, and put into a 20 degree freezer they immediately begin to accumulate at a faster rate. If we can figure out a way to stop the SOD1 proteins to aggregate in the freezer, then there is a chance that it will give us more insight as to how we can stop it in the first place.
This is currently a very crude look as to what SOD1 is, and some of the information may be incorrect. As I gain more information I will update the pages.
When the aggregates are isolated, by sonication and centrifugation, and put into a 20 degree freezer they immediately begin to accumulate at a faster rate. If we can figure out a way to stop the SOD1 proteins to aggregate in the freezer, then there is a chance that it will give us more insight as to how we can stop it in the first place.
This is currently a very crude look as to what SOD1 is, and some of the information may be incorrect. As I gain more information I will update the pages.